Research Comparison

Peptide Comparisons

Side-by-side analysis of popular peptides to help you make informed research decisions

BPC-157 vs TB-500 Semaglutide vs Tirzepatide GHK-Cu vs Matrixyl Ipamorelin vs GHRP-6

BPC-157 vs TB-500

The two most popular healing peptides compared

Factor BPC-157 TB-500
Origin Derived from human gastric juice protein Synthetic version of Thymosin Beta-4 (naturally in all cells)
Primary Mechanism Angiogenesis, VEGF, growth factor modulation Actin regulation, cell migration
Best For Tendons, ligaments, gut healing, localized injuries Soft tissue, muscle, systemic healing, flexibility
Administration Subcutaneous near injury site, oral for gut Subcutaneous anywhere (systemic effect)
Typical Dosing 200-300mcg, 1-2x daily 2-2.5mg, 2x weekly (loading), then weekly
Onset of Effects 1-2 weeks 2-4 weeks
Research Volume Extensive animal studies Moderate animal studies
Choose BPC-157 When...
  • You have a specific tendon or ligament injury
  • You want to inject near the injury site
  • You have gut/digestive issues
  • You prefer more frequent, smaller doses
  • You want more extensively researched option
Choose TB-500 When...
  • You have multiple injury sites
  • You want systemic healing support
  • Flexibility and mobility are priorities
  • You prefer less frequent dosing
  • You have soft tissue/muscle injuries
Pro Tip: Many researchers use both peptides together for synergistic effects - BPC-157 for localized healing and TB-500 for systemic support.
Full Healing Peptides Guide

Semaglutide vs Tirzepatide

Comparing the two leading GLP-1 weight loss medications

Factor Semaglutide Tirzepatide
Mechanism GLP-1 receptor agonist Dual GIP + GLP-1 receptor agonist
Brand Names Ozempic (diabetes), Wegovy (weight loss) Mounjaro (diabetes), Zepbound (weight loss)
Average Weight Loss 15-17% of body weight 20-22% of body weight
Max Dose 2.4mg weekly 15mg weekly
Oral Option Yes (Rybelsus) In development
FDA Approved Yes (2021 for weight loss) Yes (2023 for weight loss)
Long-term Data More extensive (longer on market) Growing but less than semaglutide
Cost (Branded) ~$1,000-1,400/month ~$1,000-1,400/month
Choose Semaglutide When...
  • You want longer safety track record
  • You prefer oral option (Rybelsus)
  • Insurance covers Ozempic/Wegovy
  • Moderate weight loss is your goal
  • You have type 2 diabetes
Choose Tirzepatide When...
  • You need maximum weight loss
  • Semaglutide hasn't worked well
  • You have significant insulin resistance
  • Insurance covers Mounjaro/Zepbound
  • You're comfortable with newer medication
Important: Both medications require a prescription and medical supervision. Side effects include nausea, which typically improves with proper dose titration.
Full Weight Loss Peptides Guide

GHK-Cu vs Matrixyl

Comparing top anti-aging skincare peptides

Factor GHK-Cu Matrixyl
Full Name Copper Tripeptide-1 Palmitoyl Pentapeptide-4
Mechanism Multiple: collagen, copper delivery, gene expression Signals skin to produce collagen I, III, IV
Primary Benefits Collagen, wound healing, hair, anti-inflammatory Wrinkle reduction, skin texture
Application Methods Topical, microneedling, injection Topical only
Results Timeline 4-12 weeks 8-16 weeks
Best For Anti-aging, wound healing, hair, overall skin health Fine lines, wrinkles, skin firmness
Research Level Extensive (100+ studies) Good (cosmetic-focused studies)
Choose GHK-Cu When...
  • You want multi-purpose anti-aging
  • Hair health is also a concern
  • You're recovering from procedures
  • You want wound healing benefits
  • You're open to microneedling/injection
Choose Matrixyl When...
  • You only want topical application
  • Primary focus is wrinkle reduction
  • You have sensitive skin (very gentle)
  • You want established cosmetic ingredient
  • Budget is a consideration
Pro Tip: Many skincare routines include both - GHK-Cu serums can be used alongside Matrixyl products as they work through different pathways.
Full Skincare Peptides Guide

Ipamorelin vs GHRP-6

Comparing growth hormone releasing peptides

Factor Ipamorelin GHRP-6
Type Selective GHRP Non-selective GHRP
GH Release Moderate, consistent Strong
Cortisol Impact Minimal Increases cortisol
Prolactin Impact Minimal Increases prolactin
Hunger Effect Little to none Strong hunger increase (ghrelin)
Best For Lean gains, sleep, minimal sides Mass gain, appetite increase needed
Side Effects Mild - headache, water retention More common - hunger, lethargy, water
Choose Ipamorelin When...
  • You want minimal side effects
  • You don't want increased appetite
  • Sleep improvement is a priority
  • You're sensitive to hormonal changes
  • Long-term use is planned
Choose GHRP-6 When...
  • You need strong GH release
  • Increased appetite is beneficial
  • Mass gain is the primary goal
  • Short-term use is planned
  • You can manage side effects
Full Muscle Peptides Guide

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Disclaimer: This comparison is for educational purposes only. Many peptides discussed are not FDA-approved for human use. Always consult with qualified healthcare professionals before starting any new treatment.